In 1961 House began producing his first prints at the Kelpra Studio, run by Chris and Rose Prater, where he made the earliest fine art screenprint ever to be produced in Britain. Artists such as Paolozzi and Hamilton followed in his footsteps and together they started a printmaking revolution in Britain. They cemented the medium of the screenprint in the world of fine art as opposed to the commercial sphere and secured the reputation of Kelpra in the process. Later, together with Cliff White, House set up the White Ink print studio in London, where he produced etchings and wood engravings on a series of magnificent antique printing presses he had collected. White Ink soon gained a reputation for innovative and high quality printmaking, attracting artists such as R. B. Kitaj, Richard Smith, Joe Tilson, Sidney Nolan, Victor Pasmore, Eduardo Paolozzi, Bernard Cohen and Elizabeth Frink.

Printmaking was to remain a key part of House’s oeuvre throughout the rest of his career, whether in the medium of screenprint, etching, woodcut, linocut or lithograph. In 1981 a retrospective exhibition of his graphic works opened at the Carnegie Institute, Pittsburgh, and in 1982 this travelled to the Brooklyn Museum, New York. These shows were instrumental in bringing House’s prints to the attention of a wider American audience. In the catalogue introduction Gene Baro wrote: ‘House has been remarkable for his range of apt creative vision. His ideas have been intrinsic to the mediums in which he has worked. He has so thorough an understanding of the processes of printing that he has been able to formulate his visual ideas in print terms. The overlays of ink, the particular qualities that derive from the interaction of ink with paper or from acid with plate have allowed him to create prints that are in the truest sense original’.

Gordon House was involved in the creation of some of the most iconic musical imagery of the twentieth century. This was a period when the art and music scenes were closely connected - the gallery of Robert Fraser or ‘Groovy Bob’ as he was known became a fertile meeting point for the movers and shakers in both spheres. Having designed all the stationary, cards and catalogues for the opening of Fraser’s gallery on Duke Street House was very much a part of this exciting new scene. At private views he rubbed shoulders with all the key players. In the late sixties he was regularly employed in his capacity as designer by Apple Records at their premises on Savile Row and also did work at the Rolling Stones’ offices nearby.

House collaborated with Peter Blake on the 1967 Beatles LP ‘Sgt. Pepper's Lonely Hearts Club Band’ for which he did the typography on the back cover. The pair joined forces again in the eighties on the poster designs for Live Aid. In 1968 House worked on a second Beatles release ‘The White Album’ for which he was responsible for the production and typography. After the Beatles’ break-up design commissions continued for McCartney on both his solo albums and those of ‘The Wings’. Another artist whom House was heavily involved with was Ian Dury of ‘Kilburn & the Highroads’ and ‘The Blockheads’ fame. Having designed typography for his various musical projects, in 1995 House produced the ‘What a Waste’ portfolio of screenprints in hommage to Ian.